Disease: Bicuspid aortic valve
Source: ALL
Gene Uniprot Gene Full Name Protein Class pLI DSI v DPI v
TGFBR2 P37173 transforming growth factor beta receptor 2 Kinase 0.13 0.413 0.846
TGFBR1 P36897 transforming growth factor beta receptor 1 Kinase 0.85 0.451 0.885
TGFB3 P10600 transforming growth factor beta 3 Signaling 0.99 0.498 0.808
TGFB2 P61812 transforming growth factor beta 2 Signaling 1.00 0.433 0.885
TGFB1 P01137 transforming growth factor beta 1 Signaling 3.7E-02 0.287 0.962
TBX20 Q9UMR3 T-box transcription factor 20 Transcription factor 0.97 0.663 0.346
TBL2 Q9Y4P3 transducin beta like 2 1.8E-04 0.538 0.731
SOD2 P04179 superoxide dismutase 2 Enzyme 0.15 0.379 0.923
SMAD3 P84022 SMAD family member 3 Transcription factor 0.80 0.415 0.923
SIRT1 Q96EB6 sirtuin 1 Epigenetic regulator 8.7E-02 0.378 0.885
RFC2 P35250 replication factor C subunit 2 Enzyme 2.2E-06 0.520 0.769
PRKG1 Q13976 protein kinase cGMP-dependent 1 Kinase 1.00 0.603 0.769
NOS3 P29474 nitric oxide synthase 3 6.7E-07 0.378 0.885
NKX2-5 P52952 NK2 homeobox 5 Transcription factor 0.95 0.533 0.692
MYLK Q15746 myosin light chain kinase Kinase 9.2E-12 0.510 0.846
MYH11 P35749 myosin heavy chain 11 0.77 0.528 0.731
MMP9 P14780 matrix metallopeptidase 9 Enzyme 1.9E-17 0.305 0.923
MMP2 P08253 matrix metallopeptidase 2 Enzyme 0.84 0.333 0.923
MFAP5 Q13361 microfibril associated protein 5 5.1E-03 0.590 0.615
MAT2A P31153 methionine adenosyltransferase 2A Enzyme 1.00 0.615 0.654
MAPK3 P27361 mitogen-activated protein kinase 3 Kinase 3.7E-02 0.379 0.885
MAPK1 P28482 mitogen-activated protein kinase 1 Kinase 1.00 0.330 0.923
LOX P28300 lysyl oxidase 0.99 0.447 0.846
LIMK1 P53667 LIM domain kinase 1 Kinase 1.00 0.488 0.731
GTF2IRD1 Q9UHL9 GTF2I repeat domain containing 1 0.90 0.522 0.769